Pleural Malignant Mesotheliomas Over-Express Pd-L1

Cytotoxic T Cells in PD-L1-Positive Malignant Pleural Mesotheliomas Are Counterbalanced by Distinct Immunosuppressive Factors.

PD-L1 immunohistochemical staining does not always predict whether a cancer will respond to treatment with PD-1 inhibitors. We sought to characterize immune cell infiltrates and the expression of T-cell inhibitor markers in PD-L1-positive and PD-L1-negative malignant pleural mesothelioma samples. We developed a method for immune cell phenotyping using flow cytometry on solid tumors that have be...

Two malignant pleural mesotheliomas with unusual histological features.

Morphologically, mesotheliomas may be composed of epithelial and/or sarcomatous elements with various patterns, such as tubular, papillary, tubulopapillary, and diffuse epithelial or mixtures of these. Two cases are descirbed in which, in addition to typical mesothelioma, there was cartilage with foci of calcification and ossificated with the mesothelioma, which suggested that they formed an in...

Malignant pleural mesotheliomas: an environmental health risk in southeast Turkey.

Accessible online at: www.karger.com/journals/res Natural asbestos deposits pose a health hazard not to be neglected in some European and non-European countries. According to our information, about 113 asbestos deposits are known in Turkey, of which 65% contain chrysotile, 39% tremolite and 1% crocidolite. Whereas industrial exploitation is only of minor importance, domestic and agricultural us...

Over-Expression of Immunosuppressive Molecules, PD-L1 and PD-L2, in Ulcerative Colitis Patients

Genomic Landscape of Malignant Mesotheliomas.

Understanding the genomic landscape of malignant mesothelioma may identify novel molecular drivers of this ultra-rare disease, which can lead to an expanded roster of targeted therapies and clinical trial options for patients with mesothelioma. We examined the molecular profiles of 42 patients with malignant mesothelioma (including pleural, peritoneal, and pericardial) that were referred by cli...